Article

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD <sup>+</sup> depletion at tumor edge

2020-11-27

Abstract excerpt

<h4>ABSTRACT</h4> Even after total resection of glioblastoma core lesions by surgery and aggressive post-surgical treatments, life-threatening tumors inevitably recur. A characteristic obstacle in effective treatment is high intratumoral heterogeneity, both longitudinally and spatially. Recurrence occurs predominantly at the brain parenchyma-tumor core interface, a region termed tumor edge. Given the difficulty...

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Literature Corpus work: 90879590-ba88-5924-839b-ff98af90f68f
DOI: 10.1101/2020.11.26.399725

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