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Article

Complement Membrane Attack Complexes Disrupt Proteostasis to Function as Intracellular Alarmins

2024-06-19

Abstract excerpt

<title>Abstract</title> <p> Internalized pools of membrane attack complexes (MACs) promote NF-kB and dysregulated tissue inflammation. Here, we show that C9, a MAC-associated protein, promotes loss of proteostasis to become intrinsically immunogenic. Surface-bound C9 is internalized into Rab5 + endosomes whose intraluminal acidification promotes C9 aggregates. A region within the MACPF/CDC domain of C9 stimulate...

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Literature Corpus work
80c54299-c1f8-549e-ae8e-27ca7f760e2a
DOI
10.21203/rs.3.rs-4504419/v1
Open publication

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Complement Membrane Attack Complexes Disrupt Proteostasis to Function as Intracellular AlarminsDOI 10.21203/rs.3.rs-4504419/v1
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