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Article

Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit.

Fluids and barriers of the CNS - 14 Nov 2024

Lavekar Sailee S, Hughes Jason M, Gomes Cátia, Huang Kang-Chieh, Harkin Jade, Canfield Scott G, Meyer Jason S

Abstract excerpt

Glaucoma is a neurodegenerative disease that results in the degeneration of retinal ganglion cells (RGCs) and subsequent loss of vision. While RGCs are the primary cell type affected in glaucoma, neighboring cell types selectively modulate RGCs to maintain overall homeostasis. Among these neighboring cell types, astrocytes, microvascular endothelial cells (MVECs), and pericytes coordinate with neurons to form the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39543684
DOI: 10.1186/s12987-024-00593-x
PMCID: PMC11566410

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