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Article

ApoFLARE: a luminescent reporter for direct quantification of APOBEC3A editing activity

2026-03-14

Abstract excerpt

<h4>ABSTRACT</h4> APOBEC-mediated cytidine deamination is a major endogenous source of mutagenesis in human cancers and has been linked to tumor evolution, clonal diversification and therapeutic resistance. Among the APOBEC family, APOBEC3A (A3A) is a potent and inducible cytidine deaminase, with dynamic and context-dependent activation. Most approaches for studying the role of A3A in cancer infer A3A activity in...

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Identifiers and source

Literature Corpus work
c3395d04-9d33-5ab9-a42a-e15c29c9a604
DOI
10.64898/2026.03.13.710312
Open publication

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ApoFLARE: a luminescent reporter for direct quantification of APOBEC3A editing activityDOI 10.64898/2026.03.13.710312
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