Article
Age-related Gene Expression Signatures (AGES) in rats demonstrate early, late, and linear transcriptional changes from multiple tissues
2019-07-28
Abstract excerpt
<h4>SUMMARY</h4> In order to understand changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produced a multi-timepoint Age-related Gene Expression Signature (AGES) from liver, kidney, skeletal muscle and hippocampus of rats, comparing 6, 9, 12, 18, 21, 24 and 27-month old animals. We focused on genes that changed in one direc...
Topics
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- Adipose Tissue and Metabolism
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
Identifiers and source
- Literature Corpus work
- c3180831-db4a-5d0c-aefd-6990bf2bc822
- DOI
- 10.1101/717835