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Glioblastoma Sensitization to Therapeutic Effects by Glutamine Deprivation Depends on Cellular Phenotype and Metabolism.

Biochemistry. Biokhimiia - 1 Oct 2024

Isakova Alina A, Druzhkova Irina N, Mozherov Artem M, Mazur Diana V, Antipova Nadezhda V, Krasnov Kirill S, Fadeev Roman S, Gasparian Marine E, Yagolovich Anne V

Abstract excerpt

Glutamine plays an important role in tumor metabolism. It is known that the core region of solid tumors is deprived of glutamine, which affects tumor growth and spread. Here we investigated the effect of glutamine deprivation on cellular metabolism and sensitivity of human glioblastoma cells U87MG and T98G to drugs of various origin: alkylating cytostatic agent temozolomide; cytokine TRAIL DR5-B - agonist of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39523113
DOI: 10.1134/S0006297924100079

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