Article

A Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Effective delivery of drug and gene cargos to hematopoietic stem and progenitor cells (HSPCs) is a major challenge. Current therapeutic strategies in genetic disorders or hematological malignancies are hindered by high costs, low accessibility, and high off-target toxicities. Layer-by-Layer nanoparticles (LbL NPs) are modular systems with tunable surface properties to enable highly specific targ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c308ede8-7c10-54b7-8fd2-1f4310a9bc63
DOI: 10.1101/2024.10.30.621186

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell TargetingDOI 10.1101/2024.10.30.621186Read

Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery StrategiesSemantic proximity Read

Dual-functional Nanocarrier for Improved Immunochemotherapy of Acute Myeloid LeukemiaSemantic proximity Read

Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer ImmunotherapySemantic proximity Read

Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and <i>in vivo</i> CAR T-cell engineeringSemantic proximity Read

Precision Nanotherapy for p53-Mutant Cancer Using Modular Triple-LNP DeliverySemantic proximity Read

Functional targeting of Glypican-4 by a conformation-specific single-domain antibodySemantic proximity Read

Recent Developments in Nanomedicine for Pediatric CancerSemantic proximity Read

DNA Aptamer-Polymer Conjugates for Selective Targeting of Integrin α4β1+ T-Lineage CancersSemantic proximity Read

2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticlesSemantic proximity Read

Ligand conjugated lipid-based nanocarriers for cancer theranosticsSemantic proximity Read

Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells.Semantic proximity Read

Sweet and sticky: increased cell adhesion through click-mediated functionalization of regenerative liver progenitor cellsSemantic proximity Read