Article

RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection

2025-07-05

Abstract excerpt

Liquid biopsies detect disease noninvasively by profiling cell-free nucleic acids that are secreted into the circulation. However, existing methods exhibit low sensitivity for detecting early stages of diseases such as cancer. Here we show that long-read nanopore sequencing of full-length cell-free RNA in plasma from healthy individuals, precancerous Barretts esophagus patients with high-grade dysplasia, or patien...

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Literature Corpus work: eaa2ffb7-3a3f-5210-9467-dd90860228a8
DOI: 10.1101/2025.07.02.662774

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