TF-GateNet: An Interpretable and Biologically Guided Framework for Primary-Metastatic State Prediction from Somatic Genomic Alterations.

Abstract excerpt

Metastasis remains a major cause of cancer mortality, making reliable primary-metastatic state prediction from somatic genomic alterations clinically important yet technically difficult. We present TF-GateNet, a biologically constrained neural network that combines TF-aware feature integration based on TRRUST and DoRothEA TF-gene regulatory priors with sample-specific dynamic gating on a Reactome-defined...

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