Article

Regularized sequence-context mutational trees capture variation in mutation rates across the human genome

2022-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Germline mutation is the mechanism by which genetic variation in a population is created. Inferences derived from mutation rate models are fundamental to many population genetics inference methods. Previous models have demonstrated that nucleotides flanking polymorphic sites – the local sequence context – explain variation in the probability that a site is polymorphic. However, limitations to th...

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Literature Corpus work: 4f89b51b-2db6-53b0-9e62-e6cbf77a5e47
DOI: 10.1101/2022.10.14.512160

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