Article

Functional correlation between WRN and SAMHD1 in end-resection

2024-02-16

Abstract excerpt

Double-strand breaks (DSBs) can cause chromosome rearrangements, leading to cancer and some genetic diseases. WRN and SAMHD1 are proteins implicated in DSB processing and form a complex. Our study shows that SAMHD1 influences the nuclear recruitment of WRN in response to CPT-induced DSBs. Silencing SAMHD1 restores single-stranded DNA formation in WRN-deficient cells. However, DSB accumulation from CPT treatment is...

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Literature Corpus work: c2f73a29-cc25-5235-9740-9f34a27d8e0b
DOI: 10.1101/2024.02.15.580497

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