Article

The Antiviral Activity of Triple Motif Protein 38 In Hepatitis B Virus Replication and Gene Expression and Its Association with Treatment Responses During PEG-IFN-α Antiviral Therapy

2022-10-18

Abstract excerpt

<h4>Background: </h4> Hepatitis B virus (HBV) infection is the most critical factor underlying liver cirrhosis and hepatocellular carcinoma worldwide.The triple motif protein 38 (TRIM38) is an interferon-stimulated gene (ISG) that can indirectly inhibit various DNA and RNA viruses by modulating the type I interferon response.However, the relationship between TRIM38 and HBV infection and therapy is yet to be elucid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2f105dd-15d5-5968-ba56-f344d67612e3
DOI: 10.21203/rs.3.rs-2147174/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Antiviral Activity of Triple Motif Protein 38 In Hepatitis B Virus Replication and Gene Expression and Its Association with Treatment Responses During PEG-IFN-α Antiviral TherapyDOI 10.21203/rs.3.rs-2147174/v1Read

Identification and Characterization of Multiple TRIM Proteins That Inhibit Hepatitis B Virus TranscriptionSemantic proximity Read

Comprehensive Analysis of TRIM Family Genes in Hepatitis Virus B-Related Hepatoma CarcinomaSemantic proximity Read

Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5′-UTR of TRIM22Semantic proximity Read

Analysis of Host Factor Networks during Hepatitis B Virus Infection in Primary Human HepatocytesSemantic proximity Read

Intrahepatic transcriptomics reveals gene signatures in chronic hepatitis B patients responded to interferon therapySemantic proximity Read

Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways.Semantic proximity Read

The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene ExpressionSemantic proximity Read

Evaluation of TRIM5 and TRIM22 polymorphisms on treatment responses in Iranian patients with chronic hepatitis C virus infection.Semantic proximity Read

Interplay between Hepatitis D Virus and the Interferon ResponseSemantic proximity Read

The Role of HBx Mutations in Chronic Hepatitis B with Acute Exacerbation.Semantic proximity Read

Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx DegradationSemantic proximity Read

A novel TRIM22 gene polymorphism promotes the response to PegIFNα therapy through cytokine-cytokine receptor interaction signaling pathway in chronic hepatitis B.Semantic proximity Read