Wntless interacts with Notch signaling to balance the generation of neurons and gliocytes in vertebrate dorsal diencephalon

Abstract excerpt

Wnt chaperon Wntless (Wls) mediates the intracellular transport of Wnts and plays important roles in early vertebrate brain development. Spatially restricted induction of Wls denotes the earliest differentiation of non-telencephalic cells in human brain organoids. In zebrafish developing diencephalon, loss-of-Wls reduces the formation of habenula (HA) neurons but how Wls influences HA neurogenesis is unclear and w...

Topics

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• Fluorescent Antibody Technique
• In Situ Hybridization
• Microscopy, Confocal
• Mutagenesis
• Receptors, G-Protein-Coupled
• Wnt Signaling Pathway
• Zebrafish
• Zebrafish Proteins

Identifiers and source

Literature Corpus work

c2d29328-91cd-527e-9f98-20c15e5bd33f

DOI

10.1101/2025.08.06.668881