Article

Allograft Inflammatory Factor-1 regulates immune activation states and is required for effective pathogen-specific T cell immunity during infection

2026-07-26

Abstract excerpt

Allograft inflammatory factor-1 (AIF1) is a scaffold protein expressed predominantly in myeloid antigen-presenting cells (APCs) and associated with inflammatory disease. Although genetic studies have linked AIF1 loci to immune traits, its causal role in physiological immune responses remains poorly defined. We examined AIF1 deficiency using a conditional knockout model with deletion of AIF1 in hematopoietic cells...

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Literature Corpus work: c2acada3-6acd-5a1d-9f5f-4d5bbeed5b93
DOI: 10.64898/2026.07.23.739600

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