Thymic macrophages consist of two populations with distinct localization and origin.

doi:10.7554/eLife.75148

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Article

Thymic macrophages consist of two populations with distinct localization and origin.

eLife - 30 Nov 2022

Zhou Tyng-An, Hsu Hsuan-Po, Tu Yueh-Hua, Cheng Hui-Kuei, Lin Chih-Yu, Chen Nien-Jung, Tsai Jin-Wu, Robey Ellen A, Huang Hsuan-Cheng, Hsu Chia-Lin, Dzhagalov Ivan L

Abstract excerpt

Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic macrophages to engulf apoptotic thymocytes is well appreciated, but little is known about their ontogeny, maintenance, and diversity. Here, we characterized the surface phenotype and transcriptional profile of these cells and defined their expression signature. Thymic macrophages were...

Topics

Mice
Animals
Thymus Gland
Macrophages
Thymocytes
Hematopoietic Stem Cells
Phenotype

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Identifiers

PMID: 36449334
DOI: 10.7554/eLife.75148
PMCID: PMC9754631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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