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ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

6 Mar 2019

Abstract excerpt

The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance. Autophagy has been implicated in chemoresistance, but the role of selective autophagic degradation in regulating chemoresistance remains unknown. In this study, we revealed a critical role of ABHD5 in charging CRC sensitivity to FU via regulating autophagic uracil yield. We demonstrated that ABHD5...

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PMID: 30842415
DOI: 10.1038/s41467-019-08902-x

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