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SPARC Promotes Aerobic Glycolysis and 5‐Fluorouracil Resistance in Colorectal Cancer Through the STAT3 / HK2 Axis

25 May 2025

Abstract excerpt

BACKGROUND: Chemotherapy has been used extensively in the clinic to treat colorectal cancer (CRC). Nevertheless, cancer cells usually develop chemoresistance under chemotherapy stress, leading to treatment failure. At present, the mechanism of chemoresistance in patients with CRC is not fully understood. METHODS: Firstly, Secreted protein acidic and rich in cysteine (SPARC) expression and prognosis in CRC...

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PMID: 40415238
DOI: 10.1002/cam4.70972

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