Back to search

Article

<i>C9orf72</i> repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesicles

2024-08-17

Abstract excerpt

C9orf72 hexanucleotide repeat expansion (HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The role of microglia in these C9orf72 HRE-associated diseases is understudied. To elucidate effects of C9orf72 HRE on microglia, we have characterized human induced pluripotent stem cell-derived microglia (iMG) from behavioral variant frontotemporal dementia (bvFTD) patients carry...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bb658c6e-17b3-5405-bcb2-f4a9f964bcdb
DOI
10.1101/2024.08.14.607573
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>C9orf72</i> repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesiclesDOI 10.1101/2024.08.14.607573
Cellular and molecular phenotypes of <i>C9orf72</i> ALS/FTD patient derived iPSC-microglia mono-culturesSemantic proximity
Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALSSemantic proximity
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological featuresSemantic proximity
Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALSSemantic proximity
Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegenerationSemantic proximity
Dysregulated expression of inflammasome and extracellular matrix genes in <i>C9orf72</i> -ALS/FTD microgliaSemantic proximity
Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALSSemantic proximity
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegenerationSemantic proximity
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9Semantic proximity
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microgliaSemantic proximity
Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient MiceSemantic proximity
Defects in lysosomal function and lipid metabolism in human microglia harboring a <i>TREM2</i> loss of function mutationSemantic proximity
Select a neighboring publication to make it the new centre.