Article

FGFR1 Promotes Tumor Immune Evasion via YAP-Mediated PD-L1 Expression Upregulation in Lung Squamous Cell Carcinoma

2021-08-12

Abstract excerpt

<title>Abstract</title> <p>Background: Variations in fibroblast growth factor receptor 1 (FGFR1), which occur frequently, are common driver mutations of lung squamous cell carcinoma. Immune checkpoint inhibitors targeting programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are powerful anticancer weapons. Activation of FGFR1 leads to tumorigenesis through multiple downstream molecules, including Yes-a...

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Literature Corpus work: c244d976-502f-5b9a-8abe-5cad1bb4c100
DOI: 10.21203/rs.3.rs-770194/v1

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