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Escherichia coli K88 activates NLRP3 inflammasome-mediated pyroptosis in vitro and in vivo

21 Feb 2024

Abstract excerpt

Pyroptosis induced by lipopolysaccharide (LPS) has an obvious impact on intestinal inflammation and immune regulation. Enterotoxigenic Escherichia coli (ETEC) K88 has been proved to induce inflammatory responses in several models, but whether E. coli K88 participates in the same process of pyroptotic cell death as LPS remains to be identified. We conducted a pilot experiment to confirm that E. coli K88, instead...

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PMID: 38419757
DOI: 10.1016/j.bbrep.2024.101665

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