Article

Gene conversion drives allelic dimorphism in two paralogous surface antigens of the malaria parasite <i>P. falciparum</i>

2023-02-27

Abstract excerpt

While the malaria parasite P. falciparum has low average genome-wide diversity levels, likely due to its recent introduction from a gorilla-infecting ancestor (∼10,000-50,000 years ago), some genes display extremely high diversity levels. In particular, certain proteins expressed on the surface of human red-blood-cell-infecting merozoites (merozoite surface proteins, MSPs) possess exactly two deeply-diverged alle...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c216a688-7d8a-5f5c-9082-6b473320a196
DOI: 10.1101/2023.02.27.530215

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene conversion drives allelic dimorphism in two paralogous surface antigens of the malaria parasite <i>P. falciparum</i>DOI 10.1101/2023.02.27.530215Read

Role for gene conversion in the evolution of cell-surface antigens of the malaria parasite Plasmodium falciparum.Semantic proximity Read

A new model for the origins of allelic dimorphism in Plasmodium falciparum.Semantic proximity Read

Evolution of allelic dimorphism in malarial surface antigens.Semantic proximity Read

Module-level recombination drives DBLMSP polymorphism and functional conservation in Plasmodium falciparum.Semantic proximity Read

The Plasmodium gaboni genome illuminates allelic dimorphism of immunologically important surface antigens in P. falciparum.Semantic proximity Read

Sequence diversity and evolutionary dynamics of the dimorphic antigen merozoite surface protein-6 and other Msp genes of Plasmodium falciparum.Semantic proximity Read

A paradoxical population structure of <i>var</i> DBLα types in AfricaSemantic proximity Read

Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population.Semantic proximity Read

Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence VariantsSemantic proximity Read

Evidence for the importance of genetic structuring to the structural and functional specialization of the <i>Plasmodium falciparum var</i> gene familySemantic proximity Read

Transcriptome analysis of diverse <i>Plasmodium falciparum</i> clinical isolates identifies genes correlating with highly variable expression of merozoite surface protein MSPDBL2Semantic proximity Read

Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparumSemantic proximity Read