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Article

Module-level recombination drives DBLMSP polymorphism and functional conservation in Plasmodium falciparum.

Parasite (Paris, France) - 1 Jan 2026

Duan Yi-Wen, Chen Shen-Bo, Wang Tian-Yu, Yang Wan-Xuan, Kassegne Kokouvi, Shen Hai-Mo, Chen Jun-Hu

Abstract excerpt

The DBLMSP gene family in Plasmodium falciparum encodes surface antigens involved in immune evasion and red blood cell invasion, yet its extensive polymorphism has long defied straightforward classification. While analyzing DBLMSP1 sequences from samples collected along the China-Myanmar border, we found that haplotypes could not be readily explained by standard population genetic models. Instead, comparative...

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Identifiers

PMID: 41995169
DOI: 10.1051/parasite/2026024
PMCID: PMC13088805

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