Article
The unstable hemoglobins.
Texas reports on biology and medicine - 1 Jan 2000
Carrell R W, Winterbourn C C
Abstract excerpt
The hemoglobin variants have a range of stabilities, a number being sufficiently unstable to cause a hemolytic anemia in the heterozygote. These unstable hemoglobins can be readily detected by standard stability tests. The abnormalities in the unstable hemoglobins result in an increased molecular flexibility that affects both the globin chain and the hemoglobin tetramer. The unstable globins are generally...
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