Article

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

2023-09-01

Abstract excerpt

Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these interactions. Here, we uncover a novel interaction between the viral NSP3 protein and the fragile X mental retardation proteins (FMRPs: FMR1 and FXR1-2). SARS-CoV-2 NSP3 mut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1cd10cb-2a64-5307-88cf-5c3b1cfedecd
DOI: 10.1101/2023.09.01.555899

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infectionDOI 10.1101/2023.09.01.555899Read

Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity.Semantic proximity Read

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNASemantic proximity Read

New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication ComplexesSemantic proximity Read

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilitiesSemantic proximity Read

Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 InfectionSemantic proximity Read

Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replicationSemantic proximity Read

Antagonism of stress granules key for SARS-CoV-2 infection and pathogenesisSemantic proximity Read

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replicationSemantic proximity Read

Pro-Viral and Anti-Viral Roles of the RNA-Binding Protein G3BP1Semantic proximity Read

SARS-CoV-2 Nucleocapsid Protein Targets a Conserved Surface Groove of the NTF2-like Domain of G3BP1.Semantic proximity Read

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress responseSemantic proximity Read

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAsSemantic proximity Read