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Article

Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity.

Journal of virology - 17 Feb 2026

Alvarado R Elias, Lokugamage Kumari G, Garvanska Dimitriya, Estes Leah K, Ahearn Yani, McLeland Alyssa M, Moayyed Arian, Chen Jennifer, Mendez Blanca Lopez, Plante Jessica A, Plante Kenneth S, Johnson Bryan A, Nilsson Jakob, Menachery Vineet D

Abstract excerpt

Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early stages of infection. Despite variation across the rest of the HVR, a 20-amino acid region, highly conserved in the Sarbecovirus family, is required for NSP3-FXR1...

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Identifiers

PMID: 41532757
DOI: 10.1128/jvi.02006-25
PMCID: PMC12911859

Genes

FXR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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