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Article

Genomic analysis and preclinical xenograft model development identify potential therapeutic targets for MYOD1-mutant soft-tissue sarcoma of childhood.

The Journal of pathology - 1 Sept 2021

Ting Michelle A, Reuther Jacquelyn, Chandramohan Raghu, Voicu Horatiu, Gandhi Ilavarasi, Liu Meng, Cortes-Santiago Nahir, Foster Jennifer H, Hicks John, Nuchtern Jed, Scollon Sarah, Plon Sharon E, Chintagumpala Murali, Rainusso Nino, Roy Angshumoy, Parsons D Williams

Abstract excerpt

The myogenic differentiation 1 gene (MYOD1) p.L122R somatic mutation was first discovered in a subset of clinically aggressive embryonal rhabdomyosarcomas and has since been described in both pediatric and adult spindle cell/sclerosing rhabdomyosarcomas. Relatively little is known about the clinical, molecular, and histopathological features of these tumors in children. In order to further characterize the...

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PMID: 34086347
DOI: 10.1002/path.5736

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