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Article

Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor Cells

1 Nov 2013

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, whereas undifferentiated pleomorphic sarcoma (UPS) is one of the most common soft tissue sarcomas diagnosed in adults. To investigate the myogenic cell(s) of origin of these sarcomas, we used Pax7-CreER and MyoD-CreER mice to transform Pax7(+) and MyoD(+) myogenic progenitors by expressing oncogenic Kras(G12D) and deleting Trp53 in vivo....

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Identifiers

PMID: 24239359
DOI: 10.1016/j.celrep.2013.10.020

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