Article

Discovering fragment length signatures of circulating tumor DNA using Non-negative Matrix Factorization

2021-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching both for mutational and non-mutational alterations. Recent work has shown that the length distribution of cfDNA fragments from a cancer patient can inform tumor load and type. Here, we propose non-negative matrix factorization (NMF) of fragment length distributions as a novel method to study fragment length...

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Literature Corpus work: c1c06130-c0ef-57f2-93f6-ed6d4eb2bbb5
DOI: 10.1101/2021.06.09.447533

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