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Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection

19 Oct 2016

Abstract excerpt

Adaptive changes in the genome of a locally predominant clinical isolate of the multidrug-resistant Klebsiella pneumoniae ST258 (KP35) were identified and help to explain the selection of this strain as a successful pulmonary pathogen. The acquisition of 4 new ortholog groups, including an arginine transporter, enabled KP35 to outcompete related ST258 strains lacking these genes. KP35 infection elicited a...

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PMID: 27777978
DOI: 10.1172/jci.insight.89704

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