Article

Simple Sequence Repeats Mediate Phase Variation of the Mucoid Phenotype in Hypervirulent <i>Klebsiella pneumoniae</i>

2025-09-12

Abstract excerpt

Hypervirulent Klebsiella pneumoniae (HV Kp ) express a thick mucoid capsular polysaccharide which is essential for virulence and survival in the bloodstream but inhibits epithelial adhesion and invasion. The molecular mechanisms regulating capsule expression to rapidly adapt to these distinct niches are unknown. Here, we show that high frequency mutations in a poly-G repeat in the regulator of mucoid phenotype g...

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Literature Corpus work: 0379ef40-262b-5021-ae77-af623afb6ff8
DOI: 10.1101/2025.09.12.675794

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