Article

VE-cadherin RGD motifs are dispensable for cell-cell junctions, endothelial barrier function and leukocyte extravasation

2025-01-10

Abstract excerpt

VE-cadherin is a key transmembrane protein in endothelial cell-cell junctions, essential for maintaining vascular integrity and regulating selective leukocyte extravasation into inflamed tissue. The extracellular domain of human VE-cadherin contains two arginine-glycine-aspartate (RGD) motifs, which are known integrin-binding sites, particularly for integrins in the β1, β3, and β5 families. In this study, we exami...

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Literature Corpus work: c19ae142-955f-59f6-a704-ee2aead2f539
DOI: 10.1101/2025.01.08.631898

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