Article
αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation.
The Journal of cell biology - 7 Dec 2020
Benito-Jardón María, Strohmeyer Nico, Ortega-Sanchís Sheila, Bharadwaj Mitasha, Moser Markus, Müller Daniel J, Fässler Reinhard, Costell Mercedes
Abstract excerpt
Fibronectin (FN) is an essential glycoprotein of the extracellular matrix; binds integrins, syndecans, collagens, and growth factors; and is assembled by cells into complex fibrillar networks. The RGD motif in FN facilitates cell binding- and fibrillogenesis through binding to α5β1 and αv-class integrins. However, whether RGD is the sole binding site for αv-class integrins is unclear. Most notably, substituting...
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