Article
Single-cell phenotyping within transparent intact tissue through whole-body clearing.
Cell - 14 Aug 2014
Yang Bin, Treweek Jennifer B, Kulkarni Rajan P, Deverman Benjamin E, Chen Chun-Kan, Lubeck Eric, Shah Sheel, Cai Long, Gradinaru Viviana
Abstract excerpt
Understanding the structure-function relationships at cellular, circuit, and organ-wide scale requires 3D anatomical and phenotypical maps, currently unavailable for many organs across species. At the root of this knowledge gap is the absence of a method that enables whole-organ imaging. Herein, we present techniques for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and...
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