Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.

doi:10.1016/j.devcel.2024.04.020

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Article

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.

Developmental cell - 5 Aug 2024

Kelly George, Kataura Tetsushi, Panek Johan, Ma Gailing, Salmonowicz Hanna, Davis Ashley, Kendall Hannah, Brookes Charlotte, Ayine-Tora Daniel Moscoh, Banks Peter, Nelson Glyn, Dobby Laura, Pitrez Patricia R, Booth Laura, Costello Lydia, Richardson Gavin D, Lovat Penny, Przyborski Stefan, Ferreira Lino, Greaves Laura, Szczepanowska Karolina, von Zglinicki Thomas, Miwa Satomi, Brown Max, Flagler Michael, Oblong John E, Bascom Charles C, Carroll Bernadette, Reynisson Jóhannes, Korolchuk Viktor I

Abstract excerpt

Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis. However, the molecular mechanisms and the requirement of mitochondrial quality control by mitophagy for cellular physiology are poorly understood. Here, we demonstrated that primary human cells maintain highly active basal mitophagy initiated by mitochondrial superoxide signaling....

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PMID: 38897197
DOI: 10.1016/j.devcel.2024.04.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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