Article

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies

2025-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Patients with T-cell lymphomas and leukemias have overall poor outcomes due to the lack of targeted and effective treatments, particularly in the relapsed and refractory settings. Development of chimeric antigen receptor (CAR) T-cells against T-cell neoplasms is limited by a lack of discriminating T-cell antigens that allow for effective anti-tumor responses while preventing CAR T-cell fratricid...

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Identifiers and source

Literature Corpus work: 926977e5-f4ba-58e1-9981-2fa70b12dd20
DOI: 10.1101/2025.09.24.677515

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