Article
Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort.
Nature communications - 26 Oct 2020
Moen Gunn-Helen, Brumpton Ben, Willer Cristen, Åsvold Bjørn Olav, Birkeland Kåre I, Wang Geng, Neale Michael C, Freathy Rachel M, Smith George Davey, Lawlor Deborah A, Kirkpatrick Robert M, Warrington Nicole M, Evans David M
Abstract excerpt
There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse environmental factors in utero increase future risk of cardiometabolic disease. Here, we explore if a genetic risk score (GRS) of maternal SNPs associated with offspring birthweight is also associated...
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