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Article

Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing parkinsonian rodents

2023-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Age-dependent accumulation of the brain pigment neuromelanin has been implicated in the pathogenesis of Parkinson’s disease (PD). In humans, intracellular and extracellular neuromelanin levels are increased in PD postmortem brains and boosting neuromelanin production in rodents compromises neuronal function and viability and triggers a PD-like phenotype. Focused ultrasound has been shown to redu...

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Literature Corpus work
c12dbe4a-2ee4-5713-adfb-7b574986b2a2
DOI
10.1101/2023.08.08.552410
Open publication

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Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing parkinsonian rodentsDOI 10.1101/2023.08.08.552410
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