Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates

Abstract excerpt

Although neuromelanin (NMel) is a dark pigment characteristic of dopaminergic neurons in the human substantia nigra pars compacta (SNpc), its potential role in the pathogenesis of Parkinson’s disease (PD) has often been neglected since most commonly used laboratory animals lack NMel. Here we took advantage of adeno-associated viral vectors encoding the human tyrosinase gene for triggering a time-dependent NMel acc...

Topics

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• melanin and skin pigmentation
• Neurological diseases and metabolism
• Nuclear Receptors and Signaling
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

3200be7a-96f9-5e22-8683-90018f2bb8c1

DOI

10.1101/2023.08.04.551615