Article

Mitochondrial Phosphopantetheinylation is Required for Oxidative Function

2024-05-10

Abstract excerpt

4’-phosphopantetheinyl (4’PP) groups are essential co-factors added to target proteins by p hospho p antetheinyl transferase (PPTase) enzymes. Although mitochondrial 4’PP-modified proteins have been described for decades, a mitochondrially-localized PPTase has never been found in mammals. We discovered that the cytoplasmic PPTase a mino a dipate s emialdehyde d ehydrogenase p hospho p antetheinyl transfera...

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Literature Corpus work: c1253ce5-52e9-5b0c-80e6-f52d8034ae57
DOI: 10.1101/2024.05.09.592977

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