Article
[Molecular-targeted therapy for motor neuron disease].
Brain and nerve = Shinkei kenkyu no shinpo - 1 Aug 2009
Banno Haruhiko, Katsuno Masahisa, Suzuki Keisuke, Iguchi Yohei, Adachi Hiroaki, Tanaka Fumiaki, Sobue Gen
Abstract excerpt
The mechanisms underlying selective motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remain unknown. There have been several important clinical trials on the treatment of ALS and treatment efficacy studies using mouse (SOD1) models of ALS. The latter revealed that diminished mutan...
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