Article

Novel Genetic Contributors to Premature Coronary Artery Disease: Insights from Whole-Exome Sequencing in Families with Early Onset Disease

2026-06-09

Abstract excerpt

<title>Abstract</title> <p> Coronary artery disease (CAD) is a leading global cause of mortality, with genetic predisposition conferring a more than two-fold increased risk in individuals with a family history of premature disease. This study aimed to identify rare genetic variants underlying inherited premature CAD (PCAD) in familial cases. Fifty unrelated Iranian families with early-onset familial CAD/MI were...

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Literature Corpus work: c0fbeb26-a5a9-5e46-b9fc-ea27de2266b9
DOI: 10.21203/rs.3.rs-9684016/v1

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