Article
Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension-associated genes.
Biomolecules & biomedicine - 21 Jan 2026
Ullah Mohammad Fahad, Mir Rashid, Javid Jamsheed, Elfaki Imadeldin, Altemani Faisal H, Barnawi Jameel, Algehainy Naseh A, Jalal Mohammed M, Altayar Malik A, Albalawi Salem Owaid, Mustafa Syed Khalid, Yousif Aadil, Husain Eram, Tayeb Faris J, AbuDuhier Faisel M
Abstract excerpt
Coronary artery disease (CAD) represents a complex interplay of genetic, environmental, and lifestyle factors. In this study, we utilized whole-exome sequencing (WES) on 28 patients with obstructive CAD to identify rare variants that may influence clinical outcomes beyond conventional atherosclerotic risk. We examined 74 genes curated from the Genomics England PanelApp, focusing on familial hypercholesterolemia...
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