Matrix Gla protein deficiency impairs nasal septum growth, causing midface hypoplasia

Abstract excerpt

Genetic and environmental factors may lead to abnormal growth of the orofacial skeleton, affecting the overall structure of the face. In this study, we investigated the craniofacial abnormalities in a mouse model for Keutel syndrome, a rare genetic disease caused by loss-of-function mutations in the matrix Gla protein ( MGP ) gene. Keutel syndrome patients show diffuse ectopic calcification of cartilaginous...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone and Dental Protein Studies
• Share to Connective tissue disorders research
• Share to Parathyroid Disorders and Treatments