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Article

Gnas Loss Causes Chondrocyte Fate Conversion in Cranial Suture Formation

26 Feb 2022

Abstract excerpt

Calvaria development is distinct from limb formation. Craniosynostosis is a skull deformity characterized by premature cranial suture fusion due to the loss of the GNAS gene and, consequently, its encoded protein Gα s . This birth defect requires surgery, with potential lethal consequences. So far, hardly any early-stage nonsurgical interventions for GNAS loss-related craniosynostosis are available. Here, we...

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PMID: 35220829
DOI: 10.1177/00220345221075215

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