Back to search

Article

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are key features of alpacas resolving MERS-CoV infection

2020-12-22

Abstract excerpt

While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate immune responses in controlling the infection. Experimentally infected camelids clear infectious virus within one week and mount an effective adaptive immune response. Here, transcription of immune response genes was m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c0ab40bd-b741-54e6-8997-b8e9cedc2798
DOI
10.1101/2020.12.22.423939
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are key features of alpacas resolving MERS-CoV infectionDOI 10.1101/2020.12.22.423939
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are key features of alpacas resolving MERS-CoV infectionSemantic proximity
Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infectionSemantic proximity
A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune ProtectionSemantic proximity
Innate immune signatures in the nasopharynx after SARS-CoV-2 Infection and links with the clinical outcome of COVID-19 in Omicron-dominant periodSemantic proximity
Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearanceSemantic proximity
Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association With Viral Load, Independent of SymptomsSemantic proximity
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian PeninsulaSemantic proximity
How Do Deer Respiratory Epithelial Cells Weather The Initial Storm of SARS-CoV-2?Semantic proximity
Host Determinants of MERS-CoV Transmission and PathogenesisSemantic proximity
Male Sex and Age Biases Viral Burden, Viral Shedding, and Type 1 and 2 Interferon Responses During SARS-CoV-2 Infection in FerretsSemantic proximity
The IFN response in bat cells consists of canonical and non-canonical ISGs with unique temporal expression kineticsSemantic proximity
Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2Semantic proximity
Select a neighboring publication to make it the new centre.