Article

Male Sex and Age Biases Viral Burden, Viral Shedding, and Type 1 and 2 Interferon Responses During SARS-CoV-2 Infection in Ferrets

2021-01-25

Abstract excerpt

Background: The SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has led to more than 73 million COVID-19 cases and ~1.6 million deaths worldwide. Epidemiological analysis of COVID-19 severity has revealed a male sex bias which increases with age. Understanding the mechanisms underlying this disparity will not only be beneficial to host-specific treatment but will give insight into the pathogenesis of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b33e4cf-2a32-54ff-8974-5dcc277f4b4e
DOI: 10.2139/ssrn.3753375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Male Sex and Age Biases Viral Burden, Viral Shedding, and Type 1 and 2 Interferon Responses During SARS-CoV-2 Infection in FerretsDOI 10.2139/ssrn.3753375Read

Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferretsSemantic proximity Read

Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferretsSemantic proximity Read

Sex disparities in influenza: a multiscale network analysisSemantic proximity Read

Age-dependent pathogenicity of two severe fever with thrombocytopenia syndrome viruses in a ferret modelSemantic proximity Read

Influenza infection in ferrets with SARS-CoV-2 infection historySemantic proximity Read

Sex- and Age-Dependent Neuroimmune Dysregulation and Early Neurodegenerative Signatures Following SARS-CoV-2 Infection in Golden Syrian HamstersSemantic proximity Read

Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infectionSemantic proximity Read

Host response of Syrian hamster to SARS-CoV-2 infection, including differences with humans and between sexesSemantic proximity Read

Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine modelSemantic proximity Read

Host gene expression profiles in ferrets infected with genetically distinct henipavirus strainsSemantic proximity Read

Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret ModelSemantic proximity Read

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster modelSemantic proximity Read