Article
Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
The American journal of pathology - 1 May 2009
Bonuccelli Gloria, Casimiro Mathew C, Sotgia Federica, Wang Chenguang, Liu Manran, Katiyar Sanjay, Zhou Jie, Dew Elliott, Capozza Franco, Daumer Kristin M, Minetti Carlo, Milliman Janet N, Alpy Fabien, Rio Marie-Christine, Tomasetto Catherine, Mercier Isabelle, Flomenberg Neal, Frank Philippe G, Pestell Richard G, Lisanti Michael P
Abstract excerpt
Here we used the Met-1 cell line in an orthotopic transplantation model in FVB/N mice to dissect the role of the Cav-1(P132L) mutation in human breast cancer. Identical experiments were performed in parallel with wild-type Cav-1. Cav-1(P132L) up-regulated the expression of estrogen receptor-alpha as predicted, because only estrogen receptor-alpha-positive patients have been shown to harbor Cav-1(P132L) mutations....
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