Article

Interdigitating coiled-coil tetramers define the helical architecture of GFAP filaments in astrocytes

2026-02-24

Abstract excerpt

GFAP filaments are core elements of the cytoskeleton in astrocytes, shaping cellular processes and influencing central nervous system function and pathology. How these filaments are built at the molecular level has remained unclear. Using cryo-electron microscopy and cryo-electron tomography, we show that GFAP filaments are helical polymers assembled from extended and twisted coiled-coil tetramers that interdigita...

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Literature Corpus work: c084acb1-1496-5f85-937f-168812e2eb0e
DOI: 10.64898/2026.02.23.707361

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