Article

Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers in metazoans

2025-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Branched actin networks nucleated by the Arp2/3 complex play critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90 family proteins, Arp2/3 nucleates linear actin filaments. Unexpectedly, we found that human SPIN90 is a dimer that can nucleate bidirectional actin filaments. To understand the basis for this, we dete...

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Literature Corpus work: c06d6416-833c-5ede-84f0-20770daa671b
DOI: 10.1101/2025.01.31.635869

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