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Article

Direct Actin Monomer Delivery is a WASP-specific Requirement for Arp2/3 Complex Activation.

Journal of molecular biology - 15 Mar 2026

Carlson Sofia R, Nolen Brad J

Abstract excerpt

WASP family proteins activate Arp2/3 complex to nucleate branched actin filaments in diverse cellular processes. To activate, WASP proteins recruit actin monomers to Arp2/3 complex through their conserved WASP homology 2 domains, but how these recruited monomers contribute to activation of Arp2/3 complex has been unclear. Previous studies suggested potential species-specific differences: work on human Arp2/3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41581653
DOI: 10.1016/j.jmb.2026.169662
PMCID: PMC12952234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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